EPISODE · Feb 18, 2026 · 21 MIN
2. Neurobiology of the Stress Response and Experiences of Trauma
from Re LAB · host relab
In this episode we discuss trauma and trauma-informed care definitions, and learn about Dr. Bruce Perry's Model of Neurosequential Processing and Dr. Hillary McBride's Staircase Model of the Stress Response. We talk about the short- and long-term impacts of trauma. SHOW NOTES Trauma & Trauma-Informed Care Substance Abuse and Mental Health Services Administration (2014). SAMHSA's concept of trauma and guidance for a trauma-informed approach. https://store.samhsa.gov/sites/default/files/d7/priv/sma14-4884.pdf Stanford Early Life Stress and Resilience Program; Dr. Victor Carrión Huberman, A. (Host). (September 23, 2024). Dr Victor Carrión: How to Heal From Post-Traumatic Stress Disorder. https://www.youtube.com/watch?v=4RFEkGKKhdE&t=3s Bremner, J. D., Southwick, S. M., Johnson, D. R., Yehuda, R., & Charney, D. S. (1993). Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. The American Journal of Psychiatry, 150(2), 235–239. https://doi.org/10.1176/ajp.150.2.235 U.S. Centers for Disease Control and Prevention. (2025). About adverse childhood experiences. https://www.cdc.gov/aces/about/index.html Dr. Bruce Perry’s Neurosequential Processing Model Perry, B. D., Winfrey, O. (2021). What happened to you? : conversations on trauma, resilience, and healing. Flatiron Books. https://www.bdperry.com/clincal-work NTDC Classroom Trauma-Related Behaviors – State Dependent Functioning (audio description) Dr. Hillary McBride’s Staircase Model of the Stress Response McBride, H. (2021). The Wisdom of Your Body. Baker Publishing Group. https://hillarylmcbride.com/ Understanding the Stress Response Cleveland Clinic. (2024). Hypothalamic-pituitary-adrenal (HPA) axis. https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis Cleveland Clinic. (2025). Cortisol. https://my.clevelandclinic.org/health/articles/22187-cortisol Gecaite-Stonciene, J., Hughes, B. M., Kazukauskiene, N., Bunevicius, A., Burkauskas, J., Neverauskas, J., Bellani, M., & Mickuviene, N. (2022). Cortisol response to psychosocial stress, mental distress, fatigue and quality of life in coronary artery disease patients. Scientific reports, 12(1), 19373. https://doi.org/10.1038/s41598-022-23712-w Huberman, A. (Host). (2025, August 4). How to control your cortisol & overcome burnout. [Audio Podcast Episode]. In Huberman Lab. https://www.hubermanlab.com/episode/how-to-control-your-cortisol-overcome-burnout This season is brought to you by the HRSA ANE-SANE workforce development grant (T96HP42062). Re LAB provides workforce training focused on leadership development, mentorship, and support for health care professionals.
What this episode covers
In this episode we discuss trauma and trauma-informed care definitions, and learn about Dr. Bruce Perry's Model of Neurosequential Processing and Dr. Hillary McBride's Staircase Model of the Stress Response. We talk about the short- and long-term impacts of trauma. SHOW NOTES Trauma & Trauma-Informed Care Substance Abuse and Mental Health Services Administration (2014). SAMHSA's concept of trauma and guidance for a trauma-informed approach. https://store.samhsa.gov/sites/default/files/d7/priv/sma14-4884.pdf Stanford Early Life Stress and Resilience Program; Dr. Victor Carrión Huberman, A. (Host). (September 23, 2024). Dr Victor Carrión: How to Heal From Post-Traumatic Stress Disorder. https://www.youtube.com/watch?v=4RFEkGKKhdE&t=3s Bremner, J. D., Southwick, S. M., Johnson, D. R., Yehuda, R., & Charney, D. S. (1993). Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. The American Journal of Psychiatry, 150(2), 235–239. https://doi.org/10.1176/ajp.150.2.235 U.S. Centers for Disease Control and Prevention. (2025). About adverse childhood experiences. https://www.cdc.gov/aces/about/index.html Dr. Bruce Perry’s Neurosequential Processing Model Perry, B. D., Winfrey, O. (2021). What happened to you? : conversations on trauma, resilience, and healing. Flatiron Books. https://www.bdperry.com/clincal-work NTDC Classroom Trauma-Related Behaviors – State Dependent Functioning (audio description) Dr. Hillary McBride’s Staircase Model of the Stress Response McBride, H. (2021). The Wisdom of Your Body. Baker Publishing Group. https://hillarylmcbride.com/ Understanding the Stress Response Cleveland Clinic. (2024). Hypothalamic-pituitary-adrenal (HPA) axis. https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis Cleveland Clinic. (2025). Cortisol. https://my.clevelandclinic.org/health/articles/22187-cortisol Gecaite-Stonciene, J., Hughes, B. M., Kazukauskiene, N., Bunevicius, A., Burkauskas, J., Neverauskas, J., Bellani, M., & Mickuviene, N. (2022). Cortisol response to psychosocial stress, mental distress, fatigue and quality of life in coronary artery disease patients. Scientific reports, 12(1), 19373. https://doi.org/10.1038/s41598-022-23712-w Huberman, A. (Host). (2025, August 4). How to control your cortisol & overcome burnout. [Audio Podcast Episode]. In Huberman Lab. https://www.hubermanlab.com/episode/how-to-control-your-cortisol-overcome-burnout This season is brought to you by the HRSA ANE-SANE workforce development grant (T96HP42062). Re LAB provides workforce training focused on leadership development, mentorship, and support for health care professionals.
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2. Neurobiology of the Stress Response and Experiences of Trauma
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