202-sosta：空间组学数据的结构分析

这篇文章介绍了名为 sosta 的开源 Bioconductor 软件包，该软件包专为空间组学数据中的结构化分析而设计。作者指出，现有方法大多关注单个细胞，而 sosta 则专注于多细胞解剖结构的直接分析，以更好地理解生物学功能。通过使用结直肠恶性肿瘤转化和人类扁桃体生发中心的数据集，作者展示了 sosta 如何量化结构变化并识别解剖学相关的基因表达梯度。sosta 采用基于密度的重建方法来识别和表征这些结构，从而弥合了经典组织病理学和空间转录组学之间的差距。References:* Gunz, Samuel, Helena Lucia Crowell, and Mark D. Robinson. "Analysis of anatomical multi-cellular structures from spatial omics data using sosta." bioRxiv...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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