275-小鼠视觉皮层细胞多样性动态图谱

这篇文章详细介绍了对哺乳动物大脑皮层细胞类型的全面研究，利用单细胞转录组学和多模态整合方法，在小鼠视觉皮层构建了从胚胎期到成年期的细胞发育轨迹。研究定义了大约 100 种转录组细胞类型（T 型）和 28 个细胞亚类，包括谷氨酸能兴奋性神经元、GABA能抑制性神经元、神经胶质细胞、免疫细胞和血管细胞，并发现它们在物种和大脑区域间具有一致性。通过追踪这些细胞类型的分子特征和表观遗传变化，文章揭示了细胞命运决定的时间模式，例如谷氨酸能神经元分化中的非IT（nonIT）和IT（IT）细胞分离，以及神经胶质细胞在出生后的大量多样化。此外，研究还通过识别转录因子（TF）的基因调控网络 (GRNs)，解释了调控细胞类型特异性与活动依赖性基因表达的分子机制，特别是与睁眼期相关的重大转录组变化。References:* Gao Y, van Velthoven C T J, Lee C, et al....去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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275-小鼠视觉皮层细胞多样性动态图谱

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