277-Squidiff：基于扩散模型的细胞发育与扰动预测

该文章介绍了一种名为 Squidiff 的新型计算框架，这是一个基于条件去噪扩散隐式模型 (DDIM) 的生成模型，用于预测单细胞转录组学对各种环境变化（如细胞分化、基因扰动和药物处理）的反应。Squidiff 通过结合语义编码器和扩散模型，能够学习细胞的瞬态状态并预测高分辨率的转录组景观，克服了现有模型在预测动态、高分辨率转录反应方面的限制。文章通过将其应用于诱导多能干细胞 (iPSCs) 分化、非加性基因扰动和血血管类器官 (BVOs) 在中子辐照下的反应等多种生物医学场景，验证了其准确性。研究还展示了该模型如何预测粒细胞集落刺激因子 (G-CSF) 对辐照损伤的缓解作用，并讨论了其在药物发现和细胞命运决策研究中的潜力。References:* He S, Zhu Y, Tavakol D N, et al. Squidiff: Predicting cellular develo...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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