278-胎儿与成人免疫细胞图谱

这份研究提供了对人类免疫系统成熟过程的全面概览，特别是针对妊娠中期胎儿和成人。研究人员利用单细胞测序技术，绘制了包含超过280万个免疫细胞的多器官免疫细胞图谱，挑战了胎儿免疫系统处于静止状态的传统观点。研究发现，胎儿体内存在广泛的记忆和活化T细胞以及功能性造血干细胞（HSCs），甚至在非经典造血器官中也有分布，表明存在活跃的全身性免疫活动。此外，文本详细阐述了两种关键的免疫耐受机制：精氨酸酶1阳性（ARG1+）中性粒细胞的抑制作用，以及PTGES3-PTGER4信号轴对T细胞活化的抑制，这些机制对于维持胎儿免疫平衡至关重要。References: He S, Luo C L, Luo T, et al. Systemic immune activity occurs during human immune system maturation[J]. Cell, 2025.前往小宇宙评论区与主播互动

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278-胎儿与成人免疫细胞图谱

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