281-Perturb-seq绘制基因型-表型图谱

这篇研究主要介绍利用全基因组单细胞 CRISPR 筛选技术（Perturb-seq）来创建全面的基因型-表型图谱。作者们应用 CRISPR 干扰（CRISPRi）和单细胞 RNA 测序（scRNA-seq）对两种细胞系（K562 和 RPE1）中的数千个基因进行了系统性扰动。这项大规模研究使科学家能够发现新的基因功能，剖析复杂的蛋白质复合物（如 Integrator 和 ATP 合成酶）的功能模块，并识别出与染色体不稳定性（CIN）和线粒体应激反应相关的遗传调控因素。总体而言，该研究确立了全基因组 Perturb-seq 作为一种强大的工具，可用于深入理解细胞行为、基因功能和调控网络的复杂多维关系。References:* Replogle J M, Saunders R A, Pogson A N, et al. Mapping information-rich genotype-p...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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