283-应激生物学中的翻译调控

这份综述文章探讨了翻译调控在生物体应对压力的过程中所扮演的核心角色，并将其与衰老生物学紧密联系起来。文章详细考察了三种与年龄相关的应激源（蛋白质稳态丧失、氧化损伤和营养感应失调）如何影响蛋白质合成。作者解释了应激反应如何通过调节翻译过程来感知和应对细胞损伤，并比较了应激诱导的翻译程序与衰老过程中蛋白质合成的改变，讨论了这些变化对长寿和健康衰老的潜在影响是适应性的还是有害的。核心机制包括整合应激反应 (ISR) 和 mTORC1 信号通路的激活，这些通路在细胞维持平衡和应对慢性衰老压力中至关重要。References: Genuth N R, Dillin A. Translational regulation in stress biology[J]. Nature Cell Biology, 2025: 1-13.前往小宇宙评论区与主播互动

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283-应激生物学中的翻译调控

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