289-内在细胞状态与病毒易感性

这篇文章探讨了细胞固有的可变状态而非仅宿主因子，如何决定其对病毒感染的易感性。研究人员利用“Rewind”这一回顾性单细胞克隆追踪技术，成功鉴定了宿主细胞在感染发生前的转录特征。结果显示，处于 TIG1高表达状态的细胞，通过增强病毒进入机制的因素（如AXL和TSPAN8），对SARS-CoV-2（包括原始株和Omicron变体）表现出高度易感。与此不同，流感A病毒的易感性则集中于另一个独特的细胞亚群，该亚群以 KRT8和CD46 等基因表达为标志，证明了易感状态具有病毒特异性。此外，该研究将 TIG1高表达细胞状态映射到了人肺组织中的纤毛细胞和棒状细胞，发现它与肺部炎症病理和吸烟行为相关，提示个体间的细胞状态差异可能影响疾病严重程度。References:* Reffsin S, Miller J, Ayyanathan K, et al. Single-cell suscepti...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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289-内在细胞状态与病毒易感性

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