297-cSplotch：结肠衰老的时空组织与细胞图谱

这篇关于结肠衰老过程中组织和细胞时空动态变化的论文，主要介绍了作者构建小鼠结肠细胞和空间图谱的研究工作。研究团队结合了空间转录组学（spatial transcriptomics）和单核 RNA 测序（single-nucleus RNA-sequencing）数据，并开发了一个名为 cSplotch 的计算框架。该框架利用分层贝叶斯模型整合组织学特征与分子数据，以识别与年龄、解剖区域和性别相关的空间分辨细胞表达模式，从而深入理解大肠衰老过程中的细胞和分子变化。研究结果揭示了沿结肠轴向和隐窝轴向的细胞和分子梯度，以及与衰老相关的多细胞程序。References:* Daly A C, Cambuli F, Äijö T, et al. Tissue and cellular spatiotemporal dynamics in colon aging[J]. Nature biotec...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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This episode was published on December 6, 2025.

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这篇关于结肠衰老过程中组织和细胞时空动态变化的论文，主要介绍了作者构建小鼠结肠细胞和空间图谱的研究工作。研究团队结合了空间转录组学（spatial transcriptomics）和单核 RNA 测序（single-nucleus RNA-sequencing）数据，并开发了一个名为 cSplotch...

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