301-apCAF异质性与空间微环境解析

这一综合性研究利用跨越15种癌症的单细胞RNA测序和高分辨率空间成像技术，深入探究了癌症相关成纤维细胞（CAFs）的异质性。研究人员意外地确定了两种截然不同的抗原呈递型CAFs（apCAFs）群体：与间皮细胞相关的M-apCAFs，以及与纤维细胞相关的F-apCAFs。空间分析显示，M-apCAFs定位在癌细胞附近，而F-apCAFs则主要存在于淋巴细胞富集的免疫活性区域。至关重要的是，这两种apCAF亚型都是分泌磷蛋白1（SPP1）的主要生产者，该蛋白与肿瘤恶化和治疗抵抗密切相关。在腹膜转移和胰腺导管腺癌模型中进行的进一步功能实验证实，主要源自apCAFs的基质SPP1促进了肿瘤生长和纤维化屏障的形成。此发现以前所未有的分辨率揭示了apCAFs的细胞起源和独特的空间作用。References:* Chen X, Zhou Z, Xie L, et al. Single-cell re...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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