310-PD-1轴调控高亲和力T细胞干性

这篇研究深入探讨了在持续抗原刺激下，肿瘤引流淋巴结如何维持干细胞样CD8+ T细胞（TSL细胞）的存活和功能。研究结果表明，这些TSL细胞聚集在树突状细胞附近的特定抗原提呈生态位中，并持续接收T细胞受体信号，但同时表达高水平的PD-1抑制分子。令人意外的是，持续的抗原信号并非导致细胞走向终末效应分化，而是在抑制性PD-1通路的调控下，促进了TSL细胞的增殖和自我更新。该调控机制支持了具有最高T细胞受体亲和力的克隆选择性扩增和保留，从而确保了高效能效应细胞的持续供应。然而，研究发现PD-1检查点阻断治疗破坏了这一关键的负反馈回路，导致这些最具抗肿瘤活性的高亲和力干细胞样前体细胞过早分化或凋亡，这引发了关于免疫疗法长期有效性的重要疑问。References:* Hor J L, Schrom E C, Wong-Rolle A, et al. Inhibitory PD-1 axis ma...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

NOW PLAYING

0:00 16:58

1×

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Share this episode

Similar Episodes

The Overview Effect

Mar 10, 2026 ·5m

Ecocide, Habitat Theft & Alien Grief

Feb 16, 2026 ·26m

The Living Earth Through Different Eyes

Feb 15, 2026 ·14m

A Deeper Dive into the eco-SciFi novel, Forfeiture

Feb 14, 2026 ·15m

Visitors from 55,000 BCE

Feb 14, 2026 ·12m

540322_Jewels_Of_Kali

Oct 15, 2023 ·24m

Similar Podcasts

The Burrowing Rodent Empire - Origins gopherit This podcast includes chapter readings of the epic sci-fi story which follows Mari, Jerro and Greg as they learn and explore The Burrowing Rodent Empire. 沒有聽過的聖經靈魂學習上帝真神可以祝福來愛你我透過每天一集的播出，找出中文聖經中的一個章節來閒聊一下如何思考其中的奧妙！基督徒的生活上的點點滴滴和困惑不解也可以在這裡尋找到解決方法。每日聖經查詢分享經驗，舒緩壓力！信仰上帝永遠愛在一起。閒聊?聆聽我的播客節目內容：詳細將聖經每一章節解説。仔細觀察聖經每一節所做的解釋由聖靈啓發的基督徒信仰智慧和我親身經驗的見證分享！敬請期待我為信徒們準備好的精美的基督徒信仰生活化見證和閲讀聖經故事分享生命經歷：如果聖經的教導不能應用在你我生命上帶來益處的話，再好的經文也是毫無意義！讓我將聖經帶入各位生活中的對話，我提供了實用的方法來實現基督徒該有的信念，並激勵你走上深刻而積極的信仰之路。如何跟隨耶穌的道路、真理、生命？閲讀聖經故事經文討論:基督徒信仰 ⋯信靠上帝耶和華的旨意及聖子耶穌的愛！跟隨耶穌成為門徒，幫助更多人認識上帝並且得到救贖生命！和天父上帝建立親密關係，聆聽上帝和耶穌的旨意。人生的目標和意義:孤獨？寂寞？絕望？悲傷？尋求被聖靈安慰嗎？中文欽定本聖經解決人生心靈信仰困擾！你今天過得怎麼樣？親愛的基督徒? 你的基督徒生活已經有平安和喜樂了嗎？我也會在我的播客節目中談論人類的苦難和悲慘的生活。基督教信仰和智慧是受聖靈和我個人經驗的啟發。 Golden Classics Great Radio Shows Entertainment Radio Golden Classics Great Radio Shows - Classic Radio Shows spanning the last 90 years. Shows from all genre, adventure, comedy, crime, horror and sci-fi. Life old radio guanyanxia Bold Venture 57 episodes：Bold Venture is the radio adventure series starring Humphrey Bogart and Lauren Bacall that originally aired in 1951-52. Bogart plays hotel and boat owner Slate Shannon, and Bacall plays his ward, Sailor Duval. The two often became entangled in tight situations when hiring their services to shady characters.Science Fiction Radio; Atom Age Adventures：This is the BEST Quality set of Science Fiction Radio shows currently available ANYWHERE IN THE WORLD!! This is a Custom Collection of what I feel are the BEST 53 Sci-Fi Radio Shows every produced, from shows like X-Minus 1, Dimension X, Suspense, Exploring Tomorrow, 2000 Plus, etc.Hall of Fantasy - 70 Episodes：Hall of Fantasy started as a local series out of Utah. It found its way onto the airwaves sporadically from 1947 to 1952. This anthology was picked up for national syndication by the Mutual network and broadcast from mid-52 through mid-53. Written and directed by Richard Thorne, a prolific and tale

Frequently Asked Questions

How long is this episode of 聊聊Sci?

This episode is 16 minutes long.

When was this 聊聊Sci episode published?

This episode was published on December 11, 2025.

What is this episode about?

这篇研究深入探讨了在持续抗原刺激下，肿瘤引流淋巴结如何维持干细胞样CD8+...

Can I download this 聊聊Sci episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.

URL copied to clipboard!