313-单细胞揭示卵巢癌WGD演化

这项研究使用单细胞全基因组和RNA测序技术，对高级别浆液性卵巢癌（HGSOC）中全基因组加倍 (WGD)的动态及其后果进行了深入分析。研究证实WGD是一个持续的突变过程，能显著增加肿瘤内的染色体不稳定性（CIN）和细胞多样性，并且研究人员开发了doubleTime方法来追踪WGD事件在肿瘤进化中的精确时间。含有高比例WGD细胞的肿瘤（WGD-high）展现出独特的表型，包括细胞周期失调和微核率升高。然而，与WGD-low肿瘤中CIN与炎症信号正相关的情况不同，WGD-high肿瘤通过转录抑制STING1蛋白等机制，主动削弱了细胞固有的抗病毒和干扰素信号传导。这些发现共同确立了WGD在HGSOC中既是推动肿瘤进化的驱动力，也是导致免疫抑制微环境形成的关键因素。References:* McPherson A, Vázquez-García I, Myers M A, et al. Ong...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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313-单细胞揭示卵巢癌WGD演化

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这项研究使用单细胞全基因组和RNA测序技术，对高级别浆液性卵巢癌（HGSOC）中全基因组加倍...

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