322-膜电位感知机械力与细胞密度调控

该研究详细阐述了细胞调控生长和维持组织稳态的基本机制，将物理限制与生化信号传导联系起来。研究人员发现，组织密度的增加与细胞生物量密度的增加以及更负的膜电位（超极化）直接相关，这种电位变化作为感应机械压力的全身性传感器。该膜电位继而直接调控关键的Hippo信号通路，其中超极化会阻止促进细胞生长的转录因子YAP进入细胞核。通过药理学手段使细胞去极化（膜电位不再那么负）能刺激生长，并显著提高伤口愈合的速度，而超极化则会减缓该过程。此外，研究构建了一个电-力-渗透模型，成功模拟了这些实验观察结果，证实了膜电位是连接机械力与细胞生长决策的核心机制。该发现对于理解组织再生和肿瘤发生的机制具有重要意义。References:* Mukherjee A, Huang Y, Elgeti J, et al. Membrane potential mediates the cellular respons...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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322-膜电位感知机械力与细胞密度调控

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