331-中性粒细胞转录组全景图谱

这篇文章描述了一项广泛的单细胞RNA测序研究，旨在构建一个全面的中性粒细胞转录组图谱，称为NeuMap，横跨小鼠和人类的多种组织、发育阶段和病理生理条件。研究人员发现，尽管条件多样，中性粒细胞群落组织在一个有限的转录状态集合或“中心”中，这些中心与特定的生物学功能相关，例如免疫抑制或干扰素反应。通过使用RNA速度分析和基因敲除小鼠模型，该研究进一步阐明了细胞因子和转录因子（如JUNB）如何驱动中性粒细胞沿着NeuMap中定义的特定转录轨迹成熟和极化。最终，NeuMap被证明是一个预测性平台，可以根据血细胞的转录分布来推断宿主的病理生理状态，具有潜在的诊断价值。References:* Cerezo-Wallis, D., Rubio-Ponce, A., Richter, M. et al. Architecture of the neutrophil compartment. Nat...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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331-中性粒细胞转录组全景图谱

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