333-1,364例乳腺癌全基因组景观

这篇文章概述了一项针对 1,364 例乳腺癌病例的全基因组测序研究，重点是理解韩国人群中该疾病的基因组图景及其临床意义。研究人员确定了新的驱动基因、结构变异和拷贝数改变，并将基因组特征（如突变特征和肿瘤异质性评分）与患者的临床结果相关联，突显了其作为预后生物标志物的潜力。此外，分析发现基因组不稳定性早在肿瘤诊断前几十年就已出现，并且 ERBB2 拷贝数等特定基因组改变可以预测新辅助治疗的反应。总体而言，这些发现强调了大规模全基因组测序在推进乳腺癌精准肿瘤学方面的价值。References: Kim R, Yu J, Lim J, et al. Whole-genome landscapes of 1,364 breast cancers[J]. Nature, 2025: 1-10.前往小宇宙评论区与主播互动

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333-1,364例乳腺癌全基因组景观

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