334-干细胞驱动的灵长类晚期原肠胚发育

这篇文章详细介绍了科学家如何利用优化的三维悬浮培养系统，成功地将源自干细胞的食蟹猴胚胎模型（类胚胎）的体外培养时间推进到第25天。研究表明，这些类胚胎模型经历了原肠胚形成晚期的关键发育事件，并在形态学、组织学和单细胞转录组学方面在时间和空间上再现了自然猴胚胎的许多特征，包括神经板、造血系统和原始肠道的出现。通过基因扰动实验，该模型被证明是一个可靠的平台，用于研究灵长类动物胚胎发育的细胞和分子机制，为解决人类早期发育和出生缺陷等挑战提供了工具。References: Li J, Li J, Cao J, et al. Modelling late gastrulation in stem cell-derived monkey embryo models[J]. Nature, 2025: 1-12.前往小宇宙评论区与主播互动

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