335-TSC调控祖细胞平衡与人类皮层发育

这份研究在调控大脑皮层发育中的作用，特别是如何平衡放射状祖细胞（RG）和中间祖细胞（IP）的数量，进而影响上层神经元的生成和皮层结构组织。研究结果表明，TSC蛋白的缺失会打破RG/IP平衡，导致上层神经元数量增加、皮层连接异常以及皮层结构紊乱。此外，该研究还发现人类特有的增强子（HGEs）可能通过负向调控TSC2的表达，促进了人类大脑进化过程中上层神经元的扩张。References: Casingal C R, Nakagawa N, Yabuno-Nakagawa K, et al. TSC tunes progenitor balance and upper-layer neuron generation in neocortex[J]. Nature, 2025: 1-11.前往小宇宙评论区与主播互动

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