346-脑肿瘤中的微生物信号

该研究旨在于深入了解胶质瘤和脑转移瘤等脑肿瘤中的微生物信号，这些肿瘤的预后通常较差。研究人员对来自 221 名患者的 243 个样本进行了一项多机构前瞻性研究，结合使用荧光原位杂交、免疫组织化学和高分辨率空间成像等严格方法，确认在肿瘤、免疫和基质细胞中检测到细胞内细菌 16S rRNA 和脂多糖。虽然通过测序鉴定出与肿瘤微环境相关的细菌类群，但标准培养方法未能培养出可生长的微生物群。研究还发现，肿瘤内的 16S 细菌信号与抗微生物和免疫代谢特征在空间上存在显著相关性，并且与口服和肠道微生物群存在序列重叠，表明存在潜在的关联。这些发现确立了微生物元素作为脑肿瘤微环境的一个组成部分，为未来的机制和转化研究奠定了基础。References:* Morad G, Damania A V, Melendez B, et al. Microbial signals in primary and m...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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346-脑肿瘤中的微生物信号

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