351-RHOA调控线粒体-内质网接触位点

这项研究揭示了小 GTP 酶 RHOA 是调节线粒体与内质网接触位点（MERCS）的关键分子。通过全基因组筛选，作者发现 RHOA 能通过直接结合内质网蛋白 VAPB，从而促进其与线粒体蛋白 PTPIP51 形成桥接复合体。研究进一步证明，RHOA 及其降解途径 CUL3 的水平高低直接决定了这些细胞器间接触的紧密度，进而影响钙离子转移等重要生理功能。此外，该论文还探讨了与癌症、高血压及神经退行性疾病（如 ALS）相关的基因突变如何干扰这一调节机制。这些发现为治疗与线粒体-内质网通讯功能障碍相关的疾病提供了新的潜在靶点。References:* Yang Z, Nakajima S, Chen H, et al. RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tet...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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