369-人类多器官血管细胞图谱

这项研究构建了一个全面的人类血管细胞图谱，通过整合来自19个不同器官和组织的单细胞转录组数据，深入分析了内皮细胞和壁细胞的分子特征。研究揭示了不同器官内部及器官之间血管系统的显著异质性，明确了各类血管在生理稳态、免疫调节及组织修复中的特定功能。利用drug2cell等计算工具，科学家们还预测了临床药物对特定血管床的潜在影响，为理解药物的疗效与副作用提供了新视角。此外，该图谱还阐明了血管细胞在诸如高血压和癌症等多种疾病发病机制中的关键作用。作为一个开放获取资源，这一成果为开发针对特定血管区域的精准疗法奠定了基础。References: Barnett, S.N., Cujba, AM., Yang, L. et al. An organotypic atlas of human vascular cells. Nat Med 30, 3468–3481 (2024). doi.org前往小宇宙评论区与主播互动

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369-人类多器官血管细胞图谱

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