431-CellRank：单细胞命运映射的有向轨迹推断

该研究介绍了一种名为 CellRank 的计算框架，旨在通过单细胞数据分析预测细胞的分化命运。研究人员利用该工具分析了小鼠胰腺和肺部组织的再生过程，成功识别出调节 delta 细胞形成的新型基因。在肺部研究中，该模型揭示了一条从杯状细胞回溯到基底干细胞的非典型去分化路径。这一预测通过免疫荧光实验得到了验证，证明在组织受损后确实存在特定阶段的中间细胞。此外，文档详细阐述了该算法背后的马尔可夫链数学原理及不确定性传播的处理方法。总体而言，该方法为探索复杂生物系统中的细胞谱系演变提供了强有力的分析手段。References:* Lange, M., Bergen, V., Klein, M. et al. CellRank for directed single-cell fate mapping. Nat Methods 19, 159–170 (2022). do...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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