441-肠道微生物群与器官及干细胞移植

这篇文章探讨了肠道微生物群在器官移植和造血干细胞移植中的关键作用。研究指出，移植患者普遍存在肠道菌群失调，这受到原发疾病、手术应激及术后长期使用免疫抑制剂和抗生素的共同影响。这种微生态失衡不仅通过代谢产物影响免疫调节，还与移植物排斥反应、感染风险及受试者的长期生存率密切相关。特别的是，药理微生物学揭示了肠道细菌能直接代谢他克莫司等药物，从而改变药效与毒性。为了改善预后，科学家们正积极研究通过饮食干预、益生菌以及粪便微生物移植等手段来恢复肠道稳态。作者最后强调，将微生物组信息纳入精准医疗，有望为移植患者提供个性化的治疗方案并提升其生活质量。References:* Swarte J C, Zhang S, Bakker S J L, et al. The gut microbiome in solid-organ and haematopoietic-stem-cell transpla...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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441-肠道微生物群与器官及干细胞移植

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