495-维生素B6增强CD8+ T细胞抗肿瘤免疫机制

这项研究揭示了维生素 B6 及其活性代谢物 PLP 在提升癌症免疫疗效中的关键作用。实验表明，PLP 能够直接结合并抑制 p70S6K 激酶，从而阻止转录因子 BACH2 的磷酸化及其核外排。通过维持 BACH2 在细胞核内的活性，PLP 有效促进了 CD8+ T 细胞的干性表型并抑制其耗竭，显著增强了肿瘤浸润淋巴细胞的持久性与杀伤力。这种代谢调控机制在多种小鼠模型中实现了肿瘤退缩，并能与 PD-1 抗体疗法产生协同作用。此外，人体数据验证了相关代谢通路与癌症患者生存率的正相关性，为优化肿瘤免疫治疗提供了新的营养学干预策略。References:* Wu J, Li G, Zhou J, et al. Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells[J...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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