519-泛癌肿瘤血管单细胞全景图谱

这项研究通过分析单细胞转录组数据，构建了涵盖31种癌症类型的人类肿瘤血管系统图谱。研究人员揭示了肿瘤内皮细胞在血管生成过程中的动态演变，并特别识别出一类以APLN为标志物的尖端细胞，这类细胞与患者的预后及治疗敏感性密切相关。此外，研究深入探讨了淋巴管内皮细胞的不同分化路径，以及由内质网压力驱动的基质产生型周细胞在促进血管生成中的作用。该研究还发现了肿瘤血管系统如何通过复杂的配体-受体相互作用来调节免疫微环境，从而抑制抗肿瘤免疫反应。总而言之，这些发现为理解肿瘤血管的异质性提供了关键视角，并为优化抗血管生成疗法提供了潜在的生物标志物。References: Pan, X., Li, X., Dong, L. et al. Tumour vasculature at single-cell resolution. Nature 632, 429–436 (2024). doi.org前往小宇宙评论区与主播互动

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