627-肿瘤巨噬细胞：下一代免疫治疗靶点

这份综述深入探讨了肿瘤相关巨噬细胞（TAM）在癌症治疗中的核心地位及其功能多样性。这些免疫细胞在肿瘤内部既能促进恶性生长，也能在特定条件下杀伤癌细胞，这种差异由其发育来源和微环境决定。文章重点阐述了新一代巨噬细胞疗法，包括通过抑制“别吃我”信号增强吞噬作用、利用基因工程（如CAR-M）进行重编程，以及针对骨髓祖细胞实施源头干预。此外，作者强调了生物工程技术和人工智能设计在提高治疗精准度方面的潜力。通过建立整合空间和代谢信息的六维模型，研究者旨在将巨噬细胞转化为独立于T细胞的抗癌主力军。这种从简单清除到精准重塑巨噬细胞状态的范式转换，有望为克服免疫耐药性提供关键突破。References:* Sun X, Park M D, Merad M, et al. Macrophages: Targets for next-generation cancer immunotherapy[J]. ...去小宇宙查看完整单集简介前往小宇宙评论区与主播互动

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