64. Louis Pasteur and The History of the Vaccine

What this episode covers

“I think my hand will tremble,“ – Louis Pasteur Happy New Year! The Land of Desire is BACK with an exciting – and hopeful – story to set us off on the right track in 2021. Your happy host gets to indulge her love of epidemiology a little bit without leaving you depressed in the middle of a pandemic (she swears). This week, we’re taking a look at one of the greatest French inventions of all time. Along the way, we’ll encounter Catholic masses for dogs, the worst cruise you’ve ever heard of, and a man who came a bit too close to becoming a true mad scientist, Louis Pasteur. We’re at a turning point in medical science, so what better time to look back at how far we’ve come? This week, join me for a closer look at the history of the vaccine. Episode 64: “Louis Pasteur and the History of the Vaccine” Transcript Bienvenue and welcome back to The Land of Desire! I’m your host Diana, and I’d like to start by wishing all of you a very, very happy New Year! I know it’s been a tough winter, but there are better days ahead of us. As many of you know, I’ve always been a huge epidemiology nerd, and I’ve struggled to restrain myself in the past because I know that most of my audience really doesn’t want to hear about diseases even when we aren’t going through a major pandemic. Fair enough. So I’m excited for an excuse to turn back to my favorite subject, but I promise, in a happy, optimistic way. If 2020 was the story of a disease, 2021 is looking like the story of its cure. This week, we’re taking a look at one of the greatest French inventions of all time. Along the way, we’ll encounter Catholic masses for dogs, the worst cruise you’ve ever heard of, and a man who came a bit too close to becoming a true mad scientist, Louis Pasteur. We’re at a turning point in medical science, so what better time to look back at how far we’ve come? This week, join me for a closer look at the history of the vaccine.   On July 4, 1885, a nine year old boy named Joseph Meister was attacked by a dog near his home in the city of Alsace. As he cowered and shielded his face with his tiny hands, the dog lunged at him again and again, biting him. A nearby bricklayer heard the screams and managed to beat the dog back with a pair of crowbars, but not until Joseph sustained fourteen bites on his thighs, legs and his hand. Joseph’s mother rushed him to the local doctor, who applied carbolic acid to the wounds, but the two adults looked at one another with a terrible fear. Joseph was at risk for one of humanity’s deadliest diseases, a disease scary enough to inspire not one but two terrifying mythical monsters, a disease with a nearly 100% fatality rate, a disease which guaranteed the worst of all 19th century fates: an ugly death. Joseph was at risk for rabies. Joseph’s mother, beside herself with worry, asked the doctor what else could be done. The doctor must have known Joseph was in dire straits, because he made a radical suggestion: take the boy to Paris, he said. There’s a scientist there, a famous scientist, who thinks he may have a solution. Joseph, still in unbearable pain, accompanied his mother to the train station at once, and within 48 hours of the attack, they found themselves in one of the strangest buildings they’d ever stepped inside: this was the laboratory of the great Louis Pasteur, and it was filled with rabid dogs. In the long, strange cultural history of humans and diseases, rabies has always held a unique space in our minds – more specifically, in our amygdala, which controls fear. We’ve had rabies for just about as long as we’ve had domesticated dogs, and just about every ancient set of laws we can find has some sort of rule about how to handle wild dogs, rabid dogs, dogs who bite, and people who are bitten by dogs. The first known victim of rabies appears in a cuneifo...