Alzheimer’s Starts Decades Before Symptoms episode artwork

EPISODE · Mar 24, 2026 · 48 MIN

Alzheimer’s Starts Decades Before Symptoms

from The Early Perspective · host Avanish Srinivasan

What if Alzheimer’s disease begins decades before symptoms and you wouldn’t even know?In this episode, I’m joined by Dr. Adam Brickman, Professor of Neuropsychology at Columbia University, to break down how the brain actually ages and what’s really happening in Alzheimer’s disease.We explore the difference between normal cognitive aging and neurodegeneration, why dementia and Alzheimer’s are not the same, and how biological changes like amyloid plaques can exist long before symptoms appear.Dr. Brickman also explains why removing these plaques doesn’t necessarily cure the disease, and how factors like vascular health, lifestyle, and socioeconomic conditions shape cognitive decline.This episode offers a clearer, more accurate understanding of brain aging and what it means for prevention, treatment, and the future of neuroscience.Hosted by Avanish Srinivasan.Learn more at youngaxons.com.

What if Alzheimer’s disease begins decades before symptoms and you wouldn’t even know?In this episode, I’m joined by Dr. Adam Brickman, Professor of Neuropsychology at Columbia University, to break down how the brain actually ages and what’s really happening in Alzheimer’s disease.We explore the difference between normal cognitive aging and neurodegeneration, why dementia and Alzheimer’s are not the same, and how biological changes like amyloid plaques can exist long before symptoms appear.Dr. Brickman also explains why removing these plaques doesn’t necessarily cure the disease, and how factors like vascular health, lifestyle, and socioeconomic conditions shape cognitive decline.This episode offers a clearer, more accurate understanding of brain aging and what it means for prevention, treatment, and the future of neuroscience.Hosted by Avanish Srinivasan.Learn more at youngaxons.com.

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Alzheimer’s Starts Decades Before Symptoms

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This episode was published on March 24, 2026.

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What if Alzheimer’s disease begins decades before symptoms and you wouldn’t even know?In this episode, I’m joined by Dr. Adam Brickman, Professor of Neuropsychology at Columbia University, to break down how the brain actually ages and what’s really...

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