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Biology Does Not Scale. Physics Scales. episode artwork

EPISODE · Dec 18, 2025 · 12 MIN

Biology Does Not Scale. Physics Scales.

from Biomanufacturing & Fermentation Technology · host prasad ernala

A Pichia process for a recombinant protein was transferred from 10 L (Lab) to 12,000 L(GMP). Outcome: Catastrophic failure. Titer dropped 60%, and product quality degraded due toproteolysis.

What this episode covers

A Pichia process for a recombinant protein was transferred from 10 L (Lab) to 12,000 L(GMP). Outcome: Catastrophic failure. Titer dropped 60%, and product quality degraded due toproteolysis.

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Biology Does Not Scale. Physics Scales.

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Frequently Asked Questions

How long is this episode of Biomanufacturing & Fermentation Technology?

This episode is 12 minutes long.

When was this Biomanufacturing & Fermentation Technology episode published?

This episode was published on December 18, 2025.

What is this episode about?

A Pichia process for a recombinant protein was transferred from 10 L (Lab) to 12,000 L(GMP). Outcome: Catastrophic failure. Titer dropped 60%, and product quality degraded due toproteolysis.

Can I download this Biomanufacturing & Fermentation Technology episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.
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