PodParley PodParley
PodParley
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

EPISODE · Dec 30, 2025 · 19 MIN

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

from OrphaChat — a Rare Disease Podcast · host Robin Hendel, MD

In this episode, we explore Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN), a rare and aggressive haematologic malignancy that typically manifests with distinctive skin lesions alongside bone marrow and lymph node involvement. We discuss the diagnostic process, highlighting the essential '123456' immunophenotype (CD123, CD4, CD56) and the high frequency of occult central nervous system disease, which necessitates specific screening. Finally, we review the therapeutic landscape, including the approved CD123-targeted agent tagraxofusp, the use of acute lymphoblastic leukaemia-type chemotherapy regimens, the critical role of stem cell transplantation for durable remission, and promising emerging treatments such as pivekimab sunirine.

NOW PLAYING

Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

0:00 19:24

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Share this episode

Similar Episodes

No similar episodes found.

Similar Podcasts

MG Show MG Show The MG Show, hosted by Jeffrey Pedersen and Shannon Townsend, is a leading alternative media platform dedicated to uncovering the truth behind today’s most pressing political issues. Launched in 2019, the show has grown exponentially, offering unfiltered insights, comprehensive research, and real-time analysis. With a commitment to independent journalism and factual integrity, the MG Show empowers its audience with knowledge and encourages active participation in the political discourse. Photo Breakdown Scott Wyden Kivowitz Photo Breakdown is a podcast in which we explore the world of photography with a trusted guide, host Scott Wyden Kivowitz. His expertise and passion bring the industry to life as we explore the stories, trends, and ideas shaping it today. Join us as we dissect everything from incredible photographs and creative techniques to the latest gear releases and hot topics in the photography community.In each episode, we break down what’s happening behind the scenes - whether it’s making a powerful image, a candid discussion on industry trends, or a reflection on the tools and technology changing how we make photographs. You’ll get insights, expert opinions, and a fresh perspective on what’s top of mind for photographers right now.Anticipate short, engaging episodes brimming with ideas and inspiration. Be part of the conversation by sharing your thoughts, voice notes, and comments. Your participation is what makes our community vibrant and dynamic.It’s more than just photography - everyth The Last Outlaws Impact Studios at UTS In a History Lab season like no other, we're pulling on the threads of one of Australia's great misunderstood histories, moving beyond the myths to learn what the Aboriginal brothers Jimmy and Joe Governor faced in both life and death.Australia's budding Federation is the background setting to this remarkable story, that sees the Governor brothers tied to the inauguration of a 'new' nation and Australia's dark history of frontier violence, racial injustice and the global trade and defilement of Aboriginal ancestral remains. This Impact Studios production is a collaboration with the Governor family, UTS Faculty of Law and Jumbunna Institute for Indigenous Education and Research.The Last Outlaws teamKatherine Biber - UTS Law Professor and Chief InvestigatorAunty Loretta Parsley - Great-granddaughter of Jimmy Governor and the Governor Family Historian Leroy Parsons - Governor descendant, Narrator and Co-WriterKaitlyn Sawrey - Host, Writer and Senior ProducerFrank Lopez - Writer, Managing Next Generation Energy Systems Cambridge University Background Stakeholders working with energy systems have to make complex decisions formulated from risk-based assessments about the future. The move towards more renewables in our energy systems complicates matters even further, requiring the development of an integrated power grid and continuous and steady transformation of the UK power system. Network flows must be managed reliably under uncertain demands, uncertain supply, emerging network technologies and possible failures and, further, prices in related markets can be highly volatile. Mathematicians working with engineers and economists, can make significant contributions to address such issues, by helping to develop fit-for-purpose models for next generation energy systems. These interdisciplinary approaches are looking to address a range of associated problems, including modelling, prediction, simulation, control, market and mechanism design and optimisation. This knowledge exchange workshop was part of the four months Res
URL copied to clipboard!