EPISODE · Apr 18, 2026 · 42 MIN
CRISPR changes the world and unlocks GMO 2.0
from Modified · host modifiedgmopodcast
What is CRISPR-Cas9 and how is it going to revolutionize the world of GMO crops? References de Lange, O., Binder, A. and Lahaye, T. (2014), From dead leaf, to new life: TAL effectors as tools for synthetic biology. Plant J → Review article on TAL effectors by yours truly Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol. 1987 → Paper first describing CRISPR in 1987 Interview with the 2020 Nobel Prize laureate in chemistry, Emmanuelle Charpentier, recorded in Stockholm on 12 December 2022. Martin Jinek et al.,A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity.Science337,816-821(2012). —> First paper describing use of CRISPR as a programmable DNA endonuclease Updates on Global Regulatory Landscape for Gene-Edited Crops By Clement Dionglay, January 24, 2024 https://www.isaaa.org/blog/entry/default.asp?BlogDate=1/24/2024 -> Update on regulation of gene editing. https://sanatech-seed.com/en/221226-2/ → Article from Sanatech describing the gene-edited, High GABA tomato.
What this episode covers
What is CRISPR-Cas9 and how is it going to revolutionize the world of GMO crops? References de Lange, O., Binder, A. and Lahaye, T. (2014), From dead leaf, to new life: TAL effectors as tools for synthetic biology. Plant J → Review article on TAL effectors by yours truly Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol. 1987 → Paper first describing CRISPR in 1987 Interview with the 2020 Nobel Prize laureate in chemistry, Emmanuelle Charpentier, recorded in Stockholm on 12 December 2022. Martin Jinek et al.,A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity.Science337,816-821(2012). —> First paper describing use of CRISPR as a programmable DNA endonuclease Updates on Global Regulatory Landscape for Gene-Edited Crops By Clement Dionglay, January 24, 2024 https://www.isaaa.org/blog/entry/default.asp?BlogDate=1/24/2024 -> Update on regulation of gene editing. https://sanatech-seed.com/en/221226-2/ → Article from Sanatech describing the gene-edited, High GABA tomato.
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CRISPR changes the world and unlocks GMO 2.0
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