Hey, you're listening to Smart List. It's hosted by Jason Bateman, myself, Sean Hayes, and Will Arnett. Every episode we bring on a guest that the other two don't know about it, and it's kind of surprised. And oh, Will?
Hey, man. What's going on? Are you OK? I'm just explaining what this shows.
No, I know. I didn't want to interrupt. I'm just over here. I'm staying in my lane.
Oh, wow. You can chime in if you want. No, you had it. I feel like.
I mean, do you have anything to add? No, I think you covered it all. And I just felt, to be honest, I just felt kind of useless. You're doing the intro, and I'm just sitting here like a chump.
Well, you can say something if you want, but I feel like I got it all in. OK, it's smartless, and it's super fun. Here we go. Sorry.
You can't go to Europe. I'm sorry. I couldn't hear that. You want to chew it, swallow it.
You know, you're working right now. Do you chew while you're acting? This is serious. Just the scenery.
Just the scenery. What is it? What is it today? What's the carbohydrate today?
You know, it might be less annoying than whatever you're eating now, just eating a banana and just making that sound that everybody loves. That kind of sound. Should I do that? No, what do you have going today?
Today I was just having the end of a little bit of a cookie. Oh, blast. Did you earn it? Oh my god, I did a huge workout and a hike and everything.
What did you blast today? What was it? Tries or visor? Do me a favor.
Don't say blast. Yeah, isn't that what you always say? So gross. Oh, I just blast in my quads.
I just blasted me. God, that's such a gross word. I had my trainer come over and blast my quads. And listen, he's wearing a white, really stretched out NARU t-shirt today.
Like, it's a Henley. Same thing. It's almost looks like you're trying to make us believe that your muscles are breaking through the shirt when really that shirt would fit fine if it was the normal size. This is an extra large baby size.
So this is for like a really good boy. Or a baby that just got his cookie because he was good today. A baby that's good. Listen, fellas, today we're going to make a real dent in our smartlessness.
Today we have a scientist. Oh, I love it. Already. This is a PhD.
He is the co-founder of several biotechnology companies. He's an inventor of 35 patents. He's a co-director at the Harvard Medical School. And he has been named one of Time Magazine's 100 most influential people.
He is also a three-time runner-up of People Magazine's Sexiest Man of the Year. I'm not sure if that's, we're going to have to ask him about that. John Will, and listener, this is Dr. David Sinclair.
Dr. Oh, wow. That's a sexy man right there. Where?
Sexy, right? Yeah. So not not true. Right?
Three-time runner-up to the, did I just add that? It was only two. It wasn't three. That's an exaggeration.
Just a two-time runner-up. It was four. A quick shot of you with that beard on. I bet you're going to win it this year.
It's nice. David, thank you very, very much for joining us. Now guys, I will tell you, I had the pleasure of listening to David speak at a small casual sort of lecture-ish thingy. At someone's house?
At someone's house. And it really knocked me out. Hollywood doesn't, right, don't they? They just bring people in.
No, listen. Like, you know what? Bring somebody smart over here and let them talk to us. Like, David, basically.
I know. They couldn't get anyone else. So what's the problem? I know that would hurt.
And he said some things that really straighten me out as far as my knowledge of general health and mortality. He's a specialist in aging. And I'm going to let him talk to you about some of the things that really knocked me out. I'm going to tee you up here, David.
There is, and please tell me how dumb I am and how much I did not remember. All of us are just 10. No, no, just David. OK.
Qualified, folks. Basically, the gist I got, and then I'd love to hear all the specifics again, is that while there is a definite that we're all going to die, science and technology has now sort of given us an opportunity to have a little bit more to say about how we die, when we die, the way in which the end of our life can be enjoyed. Those are all my dumb words. But is that generally what you guys are focused on a lot?
And hopefully you'll give us some tips on how to improve that part of our life today. Yeah, sure. I think you guys all know I'm 106, though. 106.
Listen, if you could see this guy, he doesn't look at day over 30. And it's pretty impressive. Yeah. And I didn't pay you to say that.
That's kind of you. But we're exactly the same age, just. We are, aren't we? I think I remember that from that day.
Isn't that in that? I've always thought that I looked fairly young for my age of 51. David, David, I mean, come on. I've always thought that I haven't asked anybody to confirm that.
But when I look at myself every morning, noon and night, I'm like, oh, look at you. But David, doesn't look older than 35. Does he look good? Yeah.
Why do you look? Your skin is incredible, actually. Well, there's this thing on the software where you think it's called the filter. Works really well.
You guys should use it. Yeah. Right. OK.
First of all, you know that Jason's image. I don't know. Maybe you've already Googled this. But you have to guess my age and also Sean's age.
Come on, serious. Well, we'll qualify. I want you to guess her age and then tell us how will they actually look? Well, you don't want you to guess it.
And then tell us what they actually look like. Go ahead. Yeah. I'm going to regret this so bad.
Something I can face as well. Just look normal. No, it don't be nice. Like if you think we're older or whatever you want to do, just really guess.
Well, you know, I have the advantage. I've been watching all of you for a number of years. I kind of know when you put under the scene. Only a couple years for me because I just got started.
Yeah, that's true. I would have said 26 for well. Uh-huh, sure. I think we're all pretty similar in age.
I don't know. I think maybe Sean, you're a bit younger. Yeah, I probably might have. The rest of us have been around for a while.
Yeah, by a decade. Is that wrong? Yeah. Yeah.
Truly, you're 41, Sean. I'm 41. Oh, shit. I also am half a century old.
50. Wow. Thanks, guys. So listen, so we're all OK.
I just turned 50. Oh, you did? Well, yeah, yeah. But David, in 40 years, we'll probably be not shocked if we die.
But based on your research and what you can perhaps share with us today, we can make that decade more enjoyable and perhaps not our last decade. Is this maybe accurate? How do we go about doing that? Yeah.
So we're kind of at the level of the Wright Brothers. It's 1902. We're freaking out how to glide. But we do know it's possible to fly.
So we've done. My colleagues and I are about 100 leaders in the world doing this. We call it aging research. We want to do every research.
It's now a fact that modern science is caught up with aging. For a while, we ignored it. We thought it was natural, acceptable. That's BS.
It's definitely not acceptable. It's the greatest cause of pain and suffering on the planet. And if you think heart disease can, or an Alzheimer's bad, what do you think causes those? Young people don't get those diseases.
It's 1,000 times aging. And one time or 20 times these other drivers of these diseases. So my point is, if we can understand what causes aging, slow it and even reverse it and we'll get to that, then these diseases either don't happen or you can take them away. And what I was telling you, Jason, which I can tell everybody who's listening is my field and my lab at Harvard.
It's been about 20 years figuring out what are the genes that control the aging process. And we've been very successful. We have a handful of genes that seem to regulate all life forms on Earth from trees to worms, even humans. And we could even like read your genes and tell you what the chances are of you living a long time.
But now actually, there's some new stuff which is blowing my mind. And my mind takes a lot to be blown because I've seen pretty much everything happen. But what I didn't realize is that aging isn't just slowable, it's actually reversible. And we can do this in mice very easily.
We can reverse the age of the I-E-M-Ls and make them see again these old mice. We can make them run 150%, 200% on a treadmill after just a few weeks of treating. And so these are the right brothers days, right? Imagine in 20, 30 years we could have intercontinental air travel eventually go to the moon.
Do you think that you guys could in a lab maybe regrow a chance of humor? Like would that be possible? No, like how would that be? Atrophied and gone.
I just don't like working on that. It is true though that you were able to change the, instead of the gray hair on mice. Now they no longer have gray hair. That's not true, is it?
Well some people have done that. That is true. You can now reverse gray hair. Actually there's a drug on the market for cancer that these patients suddenly, I think it was 11 out of 13 patients got their hair back again, the color.
Oh, Sean. Wait, wait, wait, wait, wait, wait. What's going on? What's going on?
You need to get cancer first. Wait a minute. This is fascinating to me. Right, because like think about it.
Like, no, you can't catch cancer or leukemia. Or, so in other words, all that stuff is in us. And there are things that you can do in your life that are not good things that actually turn those little toggle switches on. And now all of a sudden you are on your way to getting cancer or leukemia or diabetes or any of the other things.
Speak a little bit about that, because that really resonated with me, David. Well, so what really is driving all of these diseases is that our bodies become like, so there's an unable to fight these diseases. We're young, if a cancer cell pops up, our bodies destroy it. Or if there's misfolded proteins for our bodies destroy it.
But we lose that ability to defend ourselves against diseases. And most people don't get that. They think diseases are inevitable. Oh, if you can stay young, physically young, you don't get them.
And what we figured out is only part of it is genetic. I know I said the genes are important, but actually only 20% of our longevity in our health and old age is from our parents. The rest is how we live our life. What we eat, when we eat, how much we eat.
So 80%, as far as nature versus nurture, it is nurture basically. 80% of how you live will dictate how you die, as opposed to hereditary. And we know that because there are these twins in Denmark that live very different lives. Well, you know them, yeah?
Yeah, yeah. Yeah, yeah. Sorry, David. Well, we know that only part of it is genetic, because these twins in Denmark, if they live very different lives, they have very different lifespans.
Got it. So basically, one of the things I remember you saying was that it was sort of very common for us to kind of die at 50, maybe 100 years ago or further. Like nowadays, you know, you die around 80, 90, 100, whatever. You were saying maybe in like 20 or 30 years, people will look back at this time and say, boy, it's so weird that everybody was OK with dying at 80.
We're now living to be 120 because of, you know, not just what David Sinclair taught us and uncovered, but this whole sort of world of technology and science, what you guys are uncovering, yeah? Yeah, sure. And multiple technologies are advancing. So we've got some of my technology, which reverses the age of cells.
We've got these wearables that are getting better and better. There are blood tests that we can do. I can take your blood, you guys, and tell you. So wait, wait, wait, what's aware?
I know what an edible is. What's a wearable? It just gets down from certain, it's a sporty bracelet. Wow.
It's just like THC-based clothing. Yeah. It had to come and it had to happen. Yeah.
So what's a wearable, David? Well, so it's one of those watches that'll monitor your heartbeat and they're getting better and better. They can tell you blood sugar. I'm wearing a ring that tells me how well I slipped and what else I got up to last night.
So I just found out about that. I was thinking I might get one because I was doing the thing. I was wearing the Woop, the sleep band. I was wearing that and I was wearing the Apple Watch.
And I'd wake up in the morning. This is true and I'd wake up in the morning and I'd look at how I slept, how many times I woke up and stuff. Because I'm a big sleep guy. Right.
I got a bit very early and I wake up early. But I believe in getting a lot of sleep. Very unemployed. Very unemployed.
Sleep will make you live longer than that, so sure. It definitely will, right? Yeah. So sleep is really good.
So I mean, this is great for all the people who go to Jason's movies and watch his shows because they get a lot of sleep. You're welcome. You're welcome. Yeah.
Little naps here and there. What a service you're doing. Sometimes it's 30 minutes, sometimes it's an hour, sometimes it's an hour and a half, full length movie. So, but listen, David, you know, everybody's interested in reversing the aging process.
I mean, it's a topic that I'm sure nobody's not interested in. So tell us about exactly if, unless I'm jumping way far ahead, can you tell us like what those are and what exactly how does that work and is it all food based? Like is it only have to do with what you eat or and what can we do on our own? Yeah, there's a lot you can actually do.
This isn't rocket science. It's actually, it's going to be easier to cure aging and cancer. In your daily life, what the kind of things that I do are eight less often. Get your heart rate up for at least 10 minutes every day or so.
I basically do what we'll do today is a good start. And the kind of foods a lot of people argue is that meat is not meat, but essentially, you don't want to overload your body with with protein, having sometimes when you're lower on proteins, so plant-based Mediterranean. That's also very good. And we as a, you know, a group of scientists, people have been saying, are we olive oil, you know, all these plant-based foods, exercise?
And nobody really understood until recently why that's good for you? It turns out these genes that we've discovered that control level on Gevonie make our bodies fight aging and disease are triggered by these lifestyles. So we can turn on our bodies defenses. It's called choramesis, so amesis means what doesn't kill you makes you stronger.
And really, it's putting your body into a state of defensive mode. Because if we just eat stuff and we're sitting around and we just watch Jason's movies, our bodies go tired and they don't react to the onslaught, which we're facing every day with chemicals and damage. And so we have ways to trigger those by being hungry sometimes, up to specific in a second. But also what's interesting is we've now found certain chemicals that also mimic diet and exercise and give you the benefits or enhance healthy lifestyle.
Yeah, because everybody's looking for a quick fix pill, anything so they don't have to, you know, exercise or do the things you're saying, they can't get anything like. Do you have the I just worked out for an hour pill? Yeah, we do. Well, we don't know if they work in humans, but in mice, I can take an old mouse and make it a marathon runner.
I'll take it. How about I just blasted my quads capsule? Yeah, you might grow some whiskers, but other than that, you'll be really healthy. Super young thighs on will.
So how do you find out if you have these, you know, genes that like the respond to it? Yeah. Well, have you guys done your genomes yet? No.
What has done your genomes? So there are companies, right? There's a famous one, 23 and neither others, and such people do it. And they tell you what variation.
So we don't pretty much have the same genes, four of us are men. So we pretty much have the same genes, but the variations on the genes and how they've controlled depends on how we live, but also what we were born with. But we can read what we got from our parents very easily. I could take your DNA in my lab tomorrow, tell you what your genome is.
It used to be a billion dollars and now it takes about a hundred bucks. So there are genes. So there's one called Fox O3, which has throughout the animal kingdom. We've got it in worms, where it was first discovered, but it's also in whales.
They can live 300 years. And in our bodies, there are certain variants that are known to be in people that live over 100. And you can just read it. So for instance, we all have two copies of each gene, and I've got one longevity version and one regular version.
And I have three kids with my wife and all three of our kids got two of the best copies. So even if they don't live very well, they haven't got a chance of making it tonight. Wow. And also, so I have a lot of longevity in my family, my great-grandma and I have 105.
Three of my grandparents died at 97, two of them at 97, one at 95, I guess. So, I'm saying, is there a medal for that? Like, where do I not know? I don't know, a trophy or something.
I feel like I... It's not a contest. So many points. And it usually skips a generation.
I used to always... Jason's people all died in boats, hauling up nets in the Mediterranean. And they'll die at like 42. OK.
But with a jug of wine broken at the feet. But my question is, I always joke that people say, why do you smoke cigarettes? I say, yeah, sometimes I smoke. I have to, because I have to unset because of the advances in medical science.
I know that they're going to make everybody live for so long and I go, I can't keep this going forever. This looks too good. So I need to offset it a little. Unfered other dudes.
It's unfair because I feel like I'm going to live to be about 130 legit. We can only hope. David, can I come over and will you draw some of my blood? He cracked himself up on that, David.
We can do that. Hey, so... Sorry, my real question was, does that make a difference? All the different sides of my family with all this longevity, does that make a difference at all?
Yeah, and can you change that as well? Well, it's difficult to change it, but we're getting better at going in and changing genes using technologies like CRISPR. But yeah, the genes are important, but remember only 20%. So, well, I'm afraid you're probably not going to make it that long unless you live a healthy lifestyle too.
And we know that people who smoke, not occasionally, but a lot, have accelerated biological age, which we can measure now. Yeah. So it might be balancing out. We'll see.
We can test it. Very good. And you said, you said, depending on what is that word you use that we have the technology, what was it called? CRISPR.
What's CRISPR? So CRISPR is about 10 years ago, scientists discovered that you can go in and actually change an exact part of a cell's DNA without an enzyme. And it's been used right now to fix genetic diseases in the eye and restore vision. And eventually, pretty much every disease this genetic can be fixed.
Wow, that's great. What about diabetes? Hang on a second. What?
Yeah, what about diabetes, potentially? What if like, Will's got, you know, humorously small feet. So if you want to go from a size 5 up to like, men's size of like... Someone say, healthy.
What's a change his foot size from a 5 to a 9? Could he go into like a Crisping tub or something? Crisping tub. Crisping.
I eat plenty of Crispy cream. Is there a tub of Crisco? Crispo that I could go into? Like fries.
Once a fries are done. Could he put his feet in there? Yeah, I think there's a change. Jason hasn't been able to feel anything below his navel for about 14 years.
So is there any way that we could revive him, so to speak? Well, the onion rings are done. No, sorry, David. The ultimate age reversal, I'd say.
Yeah. So we're brought to you in partnership with Airbnb. So jet lag with a family is a different beast. Everyone's tired, has their own needs and wants.
Flexibility in space is everything. For that kind of trip, booking a stay on Airbnb often makes more sense. International travel with family takes space. Hotels can work, but they don't always provide the flexibility, larger groups need.
A bathroom for one is not ideal for a family or, and your kids bedtime doesn't need to be your bedtime. When you book a stay on Airbnb, you can find a home with multiple bedrooms, shared living areas, and even out for space. So everyone has room to unwind. Instead of gathering in a hotel lobby, meals can be shared around a table, not on a bed.
Staying in a real neighborhood also means being closer to local cafes and markets, not just the tourist corridor. When it's time to plan your next international trip, finding a home on Airbnb can make it easier to stay together, spread out, and actually enjoy the time away. What could one do to turn on these beneficial parts of our sort of our stock system here to fight the stuff that shortens our life? Well, it's much easier changing a life than changing a jeans.
And remember, 80%. So it's very doable. So what do I do? I try to skip at least one meal a day, feel a little bit hungry, but not too bad.
I work out four times a week, so I'm trying to keep my muscles going and flexible. And then I try to keep my heart running. So every other day I'll get my heart rate up. And I try to focus on plant-based foods, but I do like a good burger occasionally.
But all of that is good. And then I take a few of the molecules that my lab has worked on as well. Because I remember what you were saying. You alluded to it a few minutes ago, which is if you can trip your system into sort of, I forget the word you use, sort of like a defensive.
Chromesis. Right. And it's triggered sometimes by hunger, not starvation, but hunger where the body thinks, oh, I might be starting to starve here. And it kind of clicks into this mode that is the molecules, the energy, the proteins, whatever it is you'll tell us, that actually start to fight the bad stuff, the cancer, the diabetes, the leukemia, whatever it may be.
We kind of activate that army and it comes out into our system while we are a little bit hungry. And that sort of speaks to kind of micro-fasting. Yes. Intermittent fasting works.
Try to be hungry for, you can do 16 versus eight hours. So you can be hungry for 16 hours. I usually dinner at seven at night and I won't eat until the next day at about noon or one. Perfect.
That's kind of perfect, right? Yeah. That's what I do. That's a good way to do it.
I'm not sure if we can whiskey late at night, it's pretty good for you. I have a whiskey drip. I'm sorry. I have a whiskey drip while I'm streaming.
Let him finish, David. Jason's gone as long as 45 minutes without food without a good run. But it is true. If you don't eat from like 6 p.m.
to like noon the next day, if you can honestly go those 18 hours every single day, you're getting yourself into a state where you're not only you're getting gorgeously lean. All right. Let's be clear. But you are killing the things that could kill you.
You are killing the things that could kill you. So you're going to be gorgeous, but for a very long time. Yes? In principle.
Yeah. That's the way to do it. And it's not that hard. If you're really starving, you're not doing intermittent fasting correctly.
You get used to it after about a week or two anyway. I'm not very good at it. I can only go for one or two meals. Look at you though.
You're being very humble. Look at you. Look at you. Look 12.
It is remarkable how young you look. I will say that. It's crazy. I'm not talking to you, Sean.
No, no, I just uncomplained myself. Sean's looking at a long full length mirror. I'm a hand mirror with me wherever I go. But let me ask you something.
So I've never met you. I'm already unbelievably fascinated by everything. But for an idiot like myself, so you are a doctor who specializes in anti-aging philosophy, science, techniques, whatever this. And Jason mentioned when he was introducing you that you have 35 patents like in what and what are they and what are they used for?
Because I all the George Foreman grill. Have you ever seen that? Yeah. Oh, yes, yours.
Yes, yours. Well, just the tilt part on it. Just the part that just drips off. Without that, you're going to eat all that fat.
But what David did, when you put it on an angle, it goes into a tray. You're going to train a trip right off the table. You'll live one. I don't need to watch the YouTube video.
The tray used to be flat. I fixed it up. It's patent number one. But tell me about it because I'm an idiot.
So so far, intermittent fasting. Check. Got that. What else can we do and what are your patents for?
Well, the exercise is real. Olive oil is good. Resverter oil and red wine is one of the molecules we worked on. It's a red wine in moderate doses.
It's good. What are moderate doses? One glass or two? I have to tell my sponsor.
I'm going to tell my sponsor. I'm in sober in every year. But if it's coming from a doctor, I'm just going to say, look, I need to go over your head on this one. But I want to kind of live a little longer.
And I know that you guys frown on the drinking in AA. But yeah, does resverter oil live in anything else other than red wine? Not really. Not in any amounts.
Capsule? Sure. You can buy it pure. Yeah.
If I stick some of that in my yogurt. You can buy it pure. Yeah, it's available. Get it from a reputable supplier.
Make sure it's a white or gray powder, not brown. That means it's bad. Not out of the back of the van. No, you don't recommend not the back of the van.
So are you recommending everybody go get their jeans tested for a hundred bucks or whatever you said? And then from that, it's determined what you should avoid or what you should increase or decrease and that's your base. And then kind of restructure your life according to those results. Yes, absolutely.
That's the way to do it. And it's called optimization. So take me, for example. I've looked at my genome.
I've talked to colleagues. What should I do? I eat this. I should do that.
I went from a blood test that said I was 58 and I was actually 48 at the time. I changed my life, changed my lifestyle, lost a bit of weight, the right things. And in that blood test, it's a bit of alchemy, but it's still somewhat interesting to do. It came back in August 31.4.
I think there was a lot you can do very quickly in a matter of months to bring your health back in terms of health. And on JB, I believe you'll hear about patents. Yes, we'll hear about the patents. And I also want to hear about diabetes because my husband has died.
You know that they took a little bit of brain matter from Jason. They said they're the brain of a three-year-old. You know about this? Yeah.
I got the youth going to the wrong part of it. I'm repointed. Yeah. The brain power.
I'm trying to age my brain now. He was writing stuff down. He wrote that down. That's how important that information was.
It's all for the deposition, Will. Oh, look at that three. There's something that I want to tell you. We think we figured out how to reverse the age of cells.
And we've done this, as I said, for the eye of old mice. Hopefully in two years, we'll have tried this in people with glaucoma, pressure in the eye. We're also now doing experiments to reverse the age of an old brain. So mice get old after about two years and they forget things.
Typical, like a human would at about age 85. Now we're going to test what happens when you turn the age of the brain back to being young again. Not to three, but let's say to the equivalent of a 20-year-old. Do you lose your memories or do you regain lost memories?
And we'll know that pretty soon. That's crazy. That's crazy. I don't know.
With all your signs, I don't know if you're going to be able to go back and fix this old soul. Enlightenment stays intact. Well, rest assured. David, what is the breakthrough that you are most excited to see if you happen to live long enough to experience?
The things that you were exposed to, like, is it living on the moon? Is it probably in your field? I bet you. It's probably not living on the moon.
Well, you know, I don't know how old our listener is. Our listener never gets old. Yeah, I'm doing my life's passion. I don't want to do anything else with my life.
I would have left a long time ago if I did want to do something else. So I'm trying to figure out how to reset the body and make it healthy again. And I think we've cracked something here. The fact that we cannot just make cells behave like they're young, but actually be young again.
Reset it. Basically back to 20-year-old from an 80-year-old in the mouse. Is that because you can start a process somewhere in a cellular area of the body and that it will sort of, for lack of probably an accurate term, metastasize across the body and make the rest of the body as young as that one spot? Because it strikes me as like, you can't just treat one cell and make that good.
They all have to become younger again. Is it sort of self-perpetually? Well, we don't know the answer. In much the same way that it does on the aging side, right?
Like all the cells kind of age and make one another age, I suppose. Well, there are certain cells that communicate other cells. So if you change the age of the brain, it looks like the brain can tell the rest of the body to be young again. But I think we're probably going to have to reprogram most of the tissues separately.
And we're working on that. What we do is we introduce three very early genes, meaning these are genes that we only have on when we're a fertilized egg and developing in the womb. And they say off when we become adults, but we find that if we turn these three genes on in a mouse that's old, it resets the clock. It resets the genome so that the cell reads it again.
But it's of course not one cell. We're resetting tens of thousands and eventually billions of cells in the body. But it's a true reset. This isn't just, oh, I'll do a bit of exercise and I'll get a little bit healthy.
Right. Right. It's not conditioning it. Yeah.
Well, we actually we built the system so that when these genes can introduce their permanent and we can turn them on just by taking an antibiotic. Doctor's cycle, for example, you might use that for a Lyme disease or something. It's very safe. And so what we do with these mice is we genetically modify their eyes.
We can damage their eyes or let them get old. And then we just give them a course of three weeks of antibiotics and they get the right back. And imagine that in a human. You reengineate your body.
So you have these three youthful genes. And every time you want to fix your body or reset your age, you just take a course of antibiotics for three weeks. Jesus Christ. What would it be similar to how some species can shed skin?
And so the old skin goes off and a new skin is right underneath it and is pushed the old stuff out and it replaces it sort of seamlessly? Yeah. You're onto something. What we think is there are species that we know can regenerate.
So you cut off a lizard's tail and it grows back. What else? You can cut off the finger of a mouse that actually can grow back. Starfish.
A lot of species we grow. Even a jellyfish. You can take a piece of jellyfish and it can grow a whole new adult. And we can also clone things.
We can clone people probably, but we haven't had permission. But you can clone dogs. Do you think someone's done it? Is there a fair chance that somebody's done it?
I don't think so. Well, the reason I think not because if that person was tracing it, they didn't have to do it. They'd be crazy enough to have a press conference. I do know somebody who cloned their dog.
That was wild. Really? Yeah. Successfully cloned it.
Yeah. I saw it. Well, my question is this. You're doing this incredible stuff.
And of course, this is going to shift the conversation of our entire existence. This is getting down to this is it. This is the most existential. So first of all, you must have a bit of time around because what we do, I've spent some time around some people who are crazy rich, you have all the resources.
And the one thing they always talk about, because it's the one thing they can't control, is their health and they're getting older. Like it makes them fucking crazy because they've got everything else. They've got billions of dollars. You can only have, you can only fly so many private jets around the world and have so many yachts.
But they're like, fuck, the one thing they want to have more than anything is youth. And they hang around with younger people because they're like vampires, etc. You must have all these incredible billionaires, these 1% are banging down your door. Do you not?
Yes. I say, hurry up. Hurry up. I want to elasticity on my skin again.
Yeah. I know if a number of people. Yeah. I bet.
I bet. Also, can I jump blind in front of them? A. Because I'm a cool guy.
They're all so fucking boring and a lot more fun to hang out with. I guarantee you. And I'm not going to name names on the air. Can you put some jet hours on the?
I can't add to jet hours. But I will say this. I can add a lot of laughs. And that plane sucks if you're not having a laugh.
A. B. Let me have it before Bateman. Because I want to start getting, I'm not saying he doesn't get to have any of the magic pills.
I want him to have it. But let me have it like a week before. What is your ultimate dream for the human race? Like, do you wish there was a pill that everybody could take?
I mean, we've been told it's all about diet and exercise our whole lives. And of course, that's the answer for everything. Everybody knows that answer. It's just up to you whether you implement that or not into your life.
But to you, what is the ultimate goal? Oh, yes. To have a pill or a combination of pills that truly resets the age of the body. And I know we've been working on this as a species for the last probably half a million million years.
But nobody's had this technology. No one's been able to take a blind mouse and reset the age of the eye and make it see again. So that's why I say it's like the right brothers, right? The right brothers.
Everyone said, come on, you can't fly humans. We're never meant to fly. But they did it. And suddenly the world changed.
And I truly believe it right that point now with aging. And has anybody ever discussed with you about the population control thing about like, I imagine if you're in the business of prolonging people's lives? I'm sure there are people not loving that because they say the world is already over populated and why are we trying to interrupt nature's course of resetting itself. And there's a great deal of money to be made on people that are not in good health.
This comes up a lot. And I've written about it. There are two sides to it. Yeah, there are certain people who will live longer that we probably don't want to live longer.
That's one of the downsides. But there's also, you look at history, I like to look at history and predict the future. You know, when people were dying in their 40s and 50s and women were dying child, both the world had a lot fewer people. But was that a better world?
And I'm over the belief that humans can innovate their way around anything. And actually, if you do the math, if we were to stop everybody dying right now, the planet wouldn't get hugely populated, not very quickly anyway. And in Europe and in the US, we're actually slowing down our population growth to the point of being negative. And so it'll be replacement.
We'll probably talk out about 11 billion on the planet. And then we'll be hopefully steady state with people living 110, 120, eventually longer than that. When do you think that'll be that people will commonly live past 100? Well, some of my colleagues often don't like it when I say these things because they want it all to be based in fact.
Whereas I'm trying to predict the future. It's always dangerous. I would say within our lifetime, there will be medicines available to slow aging and some that will reverse it. But the question also becomes great.
So you live to be 103. But what is your life like? What is your body like? The quality of life in that last decade.
Well, this is the key. This is the key question. And what we know from these animal studies, whether they're in... I've mentioned mice, but we've done a lot of people, done monkey studies, dog studies, and even studies with pills in humans.
We know that these interventions, we call them, that slow down aging. They slow down aging in the whole body. So it's not like a heart medicine that just keeps your heart healthy, but your brain gets old. It's very different.
So what you get are these animals that live a lot better and healthier. They're vibrant. And then they die much quicker. Look at humans that live over 100.
They cost about a third of the health care costs of someone who gets sick before 100. So it's also a huge cost saving as well. And these people are productive, helping with grandkids, going back to work. It's a huge boon to the economy as well.