Day One DNA: How and why the UK is betting on whole genome sequencing for every newborn

The UK is preparing to change the game for healthcare - but why, how, and what will it cost?Recently the UK government announced plans to sequence the DNA of every baby born in that country. A part of the country’s 10 Year Health Plan, the program aims to identify rare genetic diseases early, prevent harms from delayed treatment and reduce future healthcare costs for the NHS. Yet along with those potential upsides come a range of ethical and practical questions, too: who guards the sequenced data, who can access it, how can consent be informed, managed and withdrawn years later, and what is the best way to gather the genetic material required to fully sequence the DNA of 700,000 infants each year?This week, I spoke to Neil Ward of PacBio to understand more about this program, compare it to other national genome sequencing programs in Europe and Asia, and discuss the promise of unlocking the ‘language of life’.02:02               Meet Neil Ward09:10               PacBio, its mission, and its current focus17:13               The UK national newborn gene sequencing effort21:20               Ethical and practical challenges for national newborn sequencing24:34               Short-read versus long-read sequencing30:48               Dried blood spots versus cord blood35:57               Lessons for the UK from Thailand38:58               Trends in national newborn screening programs worldwide41:46               What parents and policymakers must know45:20               Exciting things in the genomics space on the horizonThis episode is brought to you by MedChemExpress.Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: The past, present, and future of genome sequencingThe next frontier in genomic technologies for rare diseasesSeven genome sequencing companies to look out for