DrBeen#58 MTHFR Gene Mutation and the Risk of Clotting

DrBeen#58 MTHFR Gene Mutation and the Risk of Clotting In the United States, 20-40% of whites and hispanics have MTHFR gene mutation (C677T). This mutation leads to reduced function of MTHFR enzyme to 65% of normal. The second most common mutation leads to reduced function of MTHFR enzyme, to 30% of normal. The result of these performance issues is reduced methyl groups' availability for methylation functions. The likelihood of clotting in the cardiovascular system increases because of the endothelial impaired function, clotting factor abnormalities, and increased levels of reactive oxygen species (ROS). DrBeen: Medical Education Onlinehttps://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/ URL list from Tuesday, June 6, 2023 Homocysteine and MTHFR Mutations | Circulationhttps://www.ahajournals.org/doi/10.1161/circulationaha.114.013311 preprints202303.0418.v2.pdffile:///C:/Users/s_mob/Downloads/preprints202303.0418.v2.pdf Folate, MTHFR Gene and Heart Healthhttps://www.gbhealthwatch.com/GND-Cardiovascular-Diseases-MTHFR.php Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/ Frontiers | Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolismhttps://www.frontiersin.org/articles/10.3389/fphar.2020.587451/full Methylenetetrahydrofolate Reductase Deficiency - Medical Genetics Summaries - NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK66131/ Contribution of genotypes in Prothrombin and Factor V Leiden to COVID‐19 and disease severity in patients at high risk for hereditary thrombophilia - Kiraz - 2023 - Journal of Medical Virology - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28457 Do MTHFR polymorphisms make you more susceptible to COVID-19? - MTHFR Support Australiahttps://mthfrsupport.com.au/2021/08/do-mthfr-polymorphisms-make-you-more-susceptible-to-covid-19/ Acute Macular Neuroretinopathy Associated With COVID-19 Infection: Is Double Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutation an Underlying Risk Factor? - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968507/ Methylenetetrahydrofolate reductase - Wikipediahttps://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.