Endogenous vs. Exogenous Glycation

In this episode of the College of Glycation series, Dr. Paul Reynolds explores how sugar-driven damage in the form of advanced glycation end products (AGEs) accelerates brain aging and contributes to Alzheimer’s, Parkinson’s, depression, and other mental health challenges. He breaks down the science of glycation and insulin resistance, showing how they disrupt brain function, fuel inflammation, and create what many researchers call “Type 3 Diabetes.”Drawing from cutting-edge research and clinical insights, Dr. Reynolds highlights why standard treatments often fall short and how nutrition—particularly ketogenic therapies and low-AGE diets—can protect and even restore brain health. Packed with practical strategies and science-backed guidance, this conversation equips listeners with the tools to reduce glycation, support cognitive performance, and take control of long-term brain health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)