Episode 1: Acid-Base Disorders — A Clinical Approach episode artwork

EPISODE · Feb 13, 2026 · 18 MIN

Episode 1: Acid-Base Disorders — A Clinical Approach

from NephBytes · host Dr Amit Kaushal

A 58-year-old man in the ICU with sepsis. pH 7.18. Bicarb 9. What's really going on?In this episode, we walk through the systematic approach to acid-base disorders — from the four-step framework you should use every time, to the anion gap pitfalls most clinicians miss. We cover Winter's formula, the delta-delta ratio, albumin correction, metabolic alkalosis (chloride-responsive vs. resistant), and RTA classification made simple.By the end, you'll have a repeatable system that catches mixed disorders other people miss.Based on core concepts from Comprehensive Clinical Nephrology (Feehally, Floege, Tonelli & Johnson), with original clinical commentary and board-style takeaways.

A 58-year-old man in the ICU with sepsis. pH 7.18. Bicarb 9. What's really going on?In this episode, we walk through the systematic approach to acid-base disorders — from the four-step framework you should use every time, to the anion gap pitfalls most clinicians miss. We cover Winter's formula, the delta-delta ratio, albumin correction, metabolic alkalosis (chloride-responsive vs. resistant), and RTA classification made simple.By the end, you'll have a repeatable system that catches mixed disorders other people miss.Based on core concepts from Comprehensive Clinical Nephrology (Feehally, Floege, Tonelli & Johnson), with original clinical commentary and board-style takeaways.

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Episode 1: Acid-Base Disorders — A Clinical Approach

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This episode was published on February 13, 2026.

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A 58-year-old man in the ICU with sepsis. pH 7.18. Bicarb 9. What's really going on?In this episode, we walk through the systematic approach to acid-base disorders — from the four-step framework you should use every time, to the anion gap pitfalls...

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