Episode 1: Pete Kirkpatrick, mRNA therapeutics and Espresso Martinis

from The Translational Mixer · host Andy Marshall

Send us Fan MailPete Kirkpatrick, Chief Editor of Nature Reviews Drug Discovery, gives Andy and JC the lowdown on a Nature Conference on RNA therapeutics and what innovations he is seeing in the field of mRNA therapies.01:44 Nature conference on RNA therapies08:11 Differences between mRNA therapeutics and mRNA vaccines14:24 mRNA chemistries18:08 mRNA manufacturing22:05 mRNA delivery27:21 Delivering LNPs to organs other than liver34:25 Targeting RNA with small molecules39:35 RNA-guided CRISPR, base and prime editing therapies48:35 Pete’s tipplePete's tipple of choice: Expresso Martini1.5 Oz vodka, 1 Oz coffee liqueur, 1.5 Oz espresso.Shake over large ice cubes for 10-12 sec and strain into a Martini glass. Garnish with roasted coffee beans.(N.B. Ideally, 1.5 Oz of espresso should come from ~20 g of ground coffee.)The Mixer music “Pour Me Another” courtesy of Smooth Moves!

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