Fasting and Glycation

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—explains how fasting is one of the most powerful and underutilized tools for resetting the glycation burden your body carries. He breaks down how the standard modern eating pattern of frequent, carbohydrate-rich meals drives near-constant glucose and insulin elevations that accelerate the formation of advanced glycation end products (AGEs). These permanent molecular modifications stiffen tissues, trigger inflammation through the RAGE receptor, and fuel the chronic diseases we associate with aging. Dr. Reynolds shows why this damage isn’t inevitable and how fasting interrupts the cycle at its root.He details the profound metabolic shifts that occur when you stop eating insulin drops, the body flips the “metabolic switch” to fat-burning and ketone production, and autophagy—the cellular recycling program—ramps up to clear out damaged, glycated proteins. Drawing on key research, he covers practical approaches including time-restricted eating, early time-restricted feeding, alternate-day fasting, extended fasts, and fasting-mimicking diets. You’ll also learn why how you break a fast matter and how these strategies improve insulin sensitivity, reduce oxidative stress, and enhance metabolic flexibility—independent of weight loss. Whether you’re new to fasting or looking to deepen your practice, this episode delivers a clear, science-backed roadmap for using one of the body’s own repair mechanisms to fight glycation and support long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)