Fructose is a Glycation Accelerant

In this episode of the College of Glycation, Dr. Paul Reynolds explores a major blind spot in metabolic health: fructose. While most discussions around sugar focus on glucose and blood sugar levels, this episode reveals why fructose may be even more damaging. Dr. Reynolds explains how fructose is metabolized almost entirely in the liver, bypassing key regulatory systems and driving fat production, insulin resistance, and oxidative stress. More importantly, fructose is significantly more reactive in the glycation process—accelerating the formation of advanced glycation end-products (AGEs) that damage tissues and promote chronic disease.Building on foundational glycation science, this episode uncovers how fructose not only glycates proteins faster than glucose but also generates highly reactive compounds like methylglyoxal, amplifying cellular damage. Dr. Reynolds challenges common assumptions about “healthy” sugars found in fruit juice and natural sweeteners, offering a clearer understanding of how modern dietary patterns contribute to long-term metabolic dysfunction. Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)