Glycation and Diabetes: A Vicious Cycle

In this episode of The College of Glycation, Dr. Paul Reynolds turns the spotlight on the destructive interplay between glycation and diabetes, revealing how advanced glycation end products (AGEs) accelerate complications like neuropathy, retinopathy, and nephropathy. He explains how elevated blood sugar levels fuel AGE formation, setting off a chain reaction of tissue damage, inflammation, and oxidative stress—especially when insulin resistance is already in play. Backed by clinical studies and decades of metabolic research, Dr. Reynolds unpacks the biochemical feedback loop that makes glycation both a cause and consequence of worsening diabetes.Listeners will come away with a powerful understanding of why glycation is more than a side effect—it's a core driver of diabetic complications. From the AGE-RAGE signaling pathway to tools like skin autofluorescence and strategies to lower dietary AGE intake, this episode equips you with practical science to fight back. Whether you're navigating type 1 or type 2 diabetes, or seeking to prevent long-term damage, Dr. Reynolds delivers compelling, evidence-based insights to help break the cycle of sugar-driven disease.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)