Glycation and Immune Dysfunction

In this episode of the College of Glycation, Dr. Paul Reynolds, Professor of Cell Biology and Physiology, dives into the powerful yet underrecognized link between glycation and immune dysfunction. Learn how advanced glycation end products (AGEs) sabotage immune defenses by impairing macrophages, weakening antibodies, and triggering chronic inflammation through the AGE-RAGE pathway. Dr. Reynolds unpacks how these sugar-related changes contribute to aging, insulin resistance, and increased risk of infection, autoimmunity, and chronic disease.Backed by cutting-edge research, this lecture also offers practical strategies to protect and restore immune health—through smart dietary choices, physical activity, and antioxidant support. Whether you're a clinician, researcher, or health-conscious listener, this episode arms you with the knowledge to fight back against glycation and strengthen your body’s first line of defense.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)