Glycation and Ketones

In this episode of the College of Glycation, Dr. Paul Reynolds unpacks the powerful relationship between ketones and glycation, revealing how the body’s natural fat-derived fuel source can counteract one of the most damaging biochemical processes in modern health. He breaks down how glycation and advanced glycation end-products (AGEs) drive inflammation, oxidative stress, insulin resistance, and accelerated aging—and then shows how ketones, especially beta-hydroxybutyrate (BHB), interrupt this cycle by lowering glucose exposure, stabilizing insulin, enhancing mitochondrial efficiency, and suppressing inflammatory pathways like the NLRP3 inflammasome.Drawing from leading research and his own laboratory findings, Dr. Reynolds explains how ketosis reduces HbA1c, protects tissues from oxidative damage, and improves metabolic flexibility—while sharing practical tools listeners can use immediately, including low-AGE cooking strategies, fasting, exercise, and targeted exogenous ketones. Whether you're looking to reverse insulin resistance, slow down the biochemical aging process, or simply optimize metabolic health, this episode offers a clear, science-backed roadmap for using ketones to protect and repair the body at the cellular level.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)