Glycation and Mental Health

In this thought-provoking episode of the College of Glycation podcast, Dr. Paul Reynolds unpacks the powerful and overlooked connection between glycation and mental health. He explores how sugar-driven molecular damage—through advanced glycation end products (AGEs)—can inflame the brain, disrupt neurotransmitters like serotonin and dopamine, and worsen conditions such as depression, anxiety, and cognitive decline. By activating the RAGE pathway and impairing insulin signaling, glycation may serve as a biochemical bridge between metabolic dysfunction and psychiatric illness.Dr. Reynolds also highlights how diet, gut health, and lifestyle choices shape this relationship, offering practical ways to reduce glycation and protect brain function. Drawing on cutting-edge research in metabolic psychiatry, he reveals how improving insulin sensitivity, supporting gut integrity, and lowering AGE burden may hold the key to restoring emotional resilience and mental clarity.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)