Glycation and Polymyalgia Rheumatica

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the surprising biochemical connection between glycation and Polymyalgia Rheumatica (PMR), a painful inflammatory disorder that limits movement and quality of life. He explains how advanced glycation end-products (AGEs) can stiffen collagen, alter fascia, and transform the interstitial fluid that should keep muscles and joints moving freely—creating the perfect environment for pain and rigidity.Drawing on recent studies, Dr. Reynolds reveals how diet, inflammation, and oxidative stress intertwine in PMR, and why reducing sugar intake may help break the cycle. He also discusses ketogenic and low-carb eating as potential tools to lower AGE burden and ease stiffness, offering practical steps for protecting connective tissue health at any age.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)