Glycation and Renal Complications

Glycation doesn’t just alter blood sugar markers—it reshapes the kidneys in ways that silently drive disease. In this episode of the College of Glycation, Dr. Paul Reynolds breaks down how advanced glycation end products (AGEs) accumulate in renal tissues, stiffen filtering membranes, damage podocytes, and trigger the inflammatory RAGE pathway that accelerates diabetic nephropathy. Drawing from decades of biochemical and clinical research, Dr. Reynolds explains why the kidneys are uniquely vulnerable to elevated glucose, how glycation ignites oxidative stress and vascular dysfunction, and why early changes like microalbuminuria signal deeper metabolic trouble ahead.You’ll also learn how diet, cooking methods, exercise, and blood sugar control influence AGE formation—and what emerging therapies may help slow or reverse this trajectory. Whether you’re navigating diabetes, protecting your long-term renal health, or simply understanding how metabolic processes shape chronic disease, this episode offers actionable insights grounded in clear, rigorous science. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)