Glycation and Skin Aging

In this eye-opening episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—takes a deep dive into how advanced glycation end products (AGEs) silently sabotage your skin and connective tissues as you age. Building on the fundamentals of glycation, Dr. Reynolds explains how sugar molecules bind to collagen and elastin, locking them into stiff, unrepairable structures that lead to wrinkles, sagging, and visible signs of aging. But the damage doesn’t stop there—AGEs trigger inflammation, oxidative stress, and impair cellular repair mechanisms, making skin not only look older but function poorly, too.Dr. Reynolds goes beyond the surface to explore how glycation reflects a deeper metabolic crisis fueled by insulin resistance. Using compelling research and clinical insights, he connects aging skin to systemic issues in blood vessels, nerves, and organs—reminding us that our skin is a mirror of internal health. From the historical roots of glycation science to modern-day tools like skin autofluorescence, this episode is packed with actionable strategies to reduce AGE burden, improve skin health, and slow the biochemical processes of aging.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)