Glycation and Yerbe Mate

In this episode of the College of Glycation, Dr. Paul Reynolds explores how yerba mate—a traditional South American infusion rich in polyphenols, xanthines, and antioxidants—may offer powerful support against glycation and its wide-ranging metabolic consequences. By breaking down the science of AGEs, oxidative stress, and glucose dysregulation, Dr. Reynolds shows how yerba mate’s bioactive compounds can help stabilize blood sugar, reduce inflammation, enhance mitochondrial function, and even boost GLP-1 through microbiome-derived metabolites. It’s a deep dive into how a centuries-old herbal drink intersects with modern biochemistry to promote healthier aging and metabolic resilience. Drawing on peer-reviewed research and findings from his own lab, Dr. Reynolds explains the mechanisms behind yerba mate’s antioxidant capacity, carbonyl trapping, incretin effects, and tissue-specific metabolic benefits. Whether you're interested in functional nutrition, metabolic health, or practical strategies to reduce glycation, this episode reveals why yerba mate may be a valuable addition to a low-AGE, anti-inflammatory lifestyle.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)