Glycation and Your Hormones

In this episode of the College of Glycation series, Dr. Paul Reynolds explores how advanced glycation end-products (AGEs) quietly disrupt the body’s hormonal systems. Moving beyond blood sugar alone, he explains how glycation damages key proteins involved in hormone production, transport, and signaling—affecting thyroid function, testosterone levels, insulin sensitivity, and fertility. Even when lab results appear normal, these molecular changes can impair how hormones actually function at the tissue level.Dr. Reynolds connects the chemistry of glycation to real-world conditions like hypothyroidism, PCOS, infertility, and metabolic dysfunction, while introducing the RAGE pathway as a major driver of chronic inflammation and hormonal imbalance. This episode offers a deeper framework for understanding the link between diet, metabolic health, and endocrine function—and what you can do to reduce glycation and protect long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)