How Biotech Startups Use CRISPR Screens to Find Drug Targ...

What this episode covers

Episode 38 of Biotech Business with Fexingo dives into how biotech startups are using CRISPR screens to systematically identify drug targets. Lucas and Luna break down the technology behind pooled CRISPR knockout screens, explain how they differ from traditional target discovery, and walk through a real example: how a startup called Maze Therapeutics used CRISPR screens to uncover a novel target for kidney disease. They also discuss the challenges of off-target effects and the shift toward in vivo screens. The episode ends with a brief, low-key note on listener support at buy me a coffee dot com slash fexingo. Perfect for anyone curious about how genomics is accelerating the first step of drug development. #CRISPR #DrugDiscovery #TargetIdentification #BiotechStartup #Genomics #MazeTherapeutics #PooledScreens #InVivoCRISPR #GeneEditing #KidneyDisease #Ganovo #BiotechBusiness #BusinessAndTechnology #FexingoBusiness #BusinessPodcast #DrugDevelopment #FunctionalGenomics #Biotech Keep every episode free: buymeacoffee.com/fexingo

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Frequently Asked Questions

How long is this episode of Biotech Business with Fexingo: Life Sciences Startups, Drug Discovery, and FDA Approvals?

This episode is 12 minutes long.

When was this Biotech Business with Fexingo: Life Sciences Startups, Drug Discovery, and FDA Approvals episode published?

This episode was published on June 8, 2026.

What is this episode about?

Episode 38 of Biotech Business with Fexingo dives into how biotech startups are using CRISPR screens to systematically identify drug targets. Lucas and Luna break down the technology behind pooled CRISPR knockout screens, explain how they differ...

Can I download this Biotech Business with Fexingo: Life Sciences Startups, Drug Discovery, and FDA Approvals episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.