How Biotech Startups Use DNA Barcodes to Track Cell Lineages

Episode 46 of Biotech Business with Fexingo dives into how biotech startups are using DNA barcoding to track cell lineages in vivo. Lucas and Luna explore a startup called Cellarity that uses barcoded cells to understand which cell types respond to a drug candidate, reducing failure rates in Phase II. They discuss the technology's origins in cancer research, its application in metabolic disease, and why investors are paying attention. The hosts compare it to other high-throughput techniques like CRISPR screens and single-cell RNA sequencing, explaining why barcoding offers higher resolution and lower cost. The episode also touches on how the method helps de-risk preclinical models and shorten development timelines. Specific numbers include a 30 percent reduction in late-stage attrition cited by early adopters, and a $50 million Series B round for Cellarity in early 2026. #DNABarcoding #CellLineage #Cellarity #DrugDiscovery #Biotech #Startups #PreclinicalModels #SingleCell #HighThroughput #InVivo #MetabolicDisease #CancerResearch #SeriesB #Business #Technology #FexingoBusiness #BusinessPodcast #BiotechBusiness Keep every episode free: buymeacoffee.com/fexingo