How McKesson Mastered Pharmaceutical Distribution episode artwork

EPISODE · May 22, 2026 · 9 MIN

How McKesson Mastered Pharmaceutical Distribution

from The Operations Podcast with Fexingo: Process, People, and Profit in Modern Business · host Fexingo

In this episode, Lucas and Luna dive into the operational genius behind McKesson—one of the world's largest pharmaceutical distributors. They explore how the company's massive DC in Olive Branch, Mississippi, processes over 100,000 unique SKUs daily with 99.9% accuracy. From the 'tote-and-chute' system to the real-time inventory algorithms that prevent drug shortages, Lucas breaks down the engineering of a supply chain most of us never see. They discuss the thin margins—around 1.5%—and how scale and precision make the business profitable. Luna asks about the bottlenecks in hospital logistics and the role of automation vs. human judgment. The episode also touches on the 2020 pandemic stress test that revealed just how resilient (and brittle) these networks can be. A fascinating look at the invisible infrastructure that gets your prescription from the manufacturer to your pharmacy. #McKesson #PharmaceuticalDistribution #SupplyChain #Operations #HealthcareLogistics #InventoryManagement #Automation #Warehouse #OliveBranch #DrugShortage #Business #BusinessPodcast #FexingoBusiness #OperationsPodcast #LucasAndLuna #ProcessPeopleProfit #DistributionCenter #PrescriptionSupplyChain Keep every episode free: buymeacoffee.com/fexingo

In this episode, Lucas and Luna dive into the operational genius behind McKesson—one of the world's largest pharmaceutical distributors. They explore how the company's massive DC in Olive Branch, Mississippi, processes over 100,000 unique SKUs daily with 99.9% accuracy. From the 'tote-and-chute' system to the real-time inventory algorithms that prevent drug shortages, Lucas breaks down the engineering of a supply chain most of us never see. They discuss the thin margins—around 1.5%—and how scale and precision make the business profitable. Luna asks about the bottlenecks in hospital logistics and the role of automation vs. human judgment. The episode also touches on the 2020 pandemic stress test that revealed just how resilient (and brittle) these networks can be. A fascinating look at the invisible infrastructure that gets your prescription from the manufacturer to your pharmacy. #McKesson #PharmaceuticalDistribution #SupplyChain #Operations #HealthcareLogistics #InventoryManagement #Automation #Warehouse #OliveBranch #DrugShortage #Business #BusinessPodcast #FexingoBusiness #OperationsPodcast #LucasAndLuna #ProcessPeopleProfit #DistributionCenter #PrescriptionSupplyChain Keep every episode free: buymeacoffee.com/fexingo

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How McKesson Mastered Pharmaceutical Distribution

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How long is this episode of The Operations Podcast with Fexingo: Process, People, and Profit in Modern Business?

This episode is 9 minutes long.

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This episode was published on May 22, 2026.

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In this episode, Lucas and Luna dive into the operational genius behind McKesson—one of the world's largest pharmaceutical distributors. They explore how the company's massive DC in Olive Branch, Mississippi, processes over 100,000 unique SKUs daily...

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